Big Willy's is the name of Orthopox's big restaurant chain. It has 500 establishments and counting, with at least three restaurants in Harbor City, Fairfield and Las Paradiso. Its main food product are hotdogs made from the skeletal muscle of all the humans that Crypto had killed in the first two games. Big Willy's hotdogs and fries are fried in motor oil and their smoothies contain leaded petrol so whoever drinks it would lose all of their taste buds which would make the hotdogs even more delicious and the lead in it makes them sweeter. This is a clearly unorthodox method for fast-food preparation, considering the infamous 1970's oil shortages, making the oil expensive to buy, and the oil's toxicity to humans.
It's main competitor is Colonel Kluckin's Kitchen run by Colonel Kluckin. After the defeat of Colonel Kluckin, Pox sold his restaurant thanks to his banker who was in a region of Vietmahl. He dropped the money thanks to something about shrimp boats and a mentally challenged war veteran.
- Destroy All Humans! Big Willy Unleashed
The game features the biggest appearance from the restaurant chain, as the story of the game gravitates around it.
In Destroy All Humans! Path of the Furon, the restaurant can be found beside the Sultan Casino Hotel where it features the prices of each meal and they have upgraded to burgers.
- Willyburger .45
- Cheese Willyburger .79
- Super Willyburger .99
- Mega Willyburger 1.25
- Atomic Willyburger 5.99
- Side orders
- Fries .39
- Onion Rings .49
- Soda .59
- Willy Whirly .89
- Wonder Willy .99
- Pox often refers to the restaurant as "my Big Willy" which bothers Crypto, as he takes it in the meaning of Pox speaking about his penis.