Doctor Orlov was introduced to Crypto by Agent Sergei in Tunguska. He worked on Project Solaris until he saw "strange things," meaning the Blisk. Crypto rescued him when his cabin was being attacked by the KGB and the Army. After being rescued by Crypto, Doctor Orlov informs Crypto that he had been working on a weapon to defeat the Blisk. Crypto finds it in Science Town and is able to destroy the Blisk.
After killing all the Blisk in Tunguska, Crypto saves Doctor Orlov from the KGB Base and returns him to a cabin in the Frozen Lake. He is mentioned briefly in scan.