E-Coli was a rich, upper-class female Furon, who worked at the Palace, whom Orthopox fell in love with during his summer internship at the Palace. It was revealed that she left Pox after her father bought her a new transportation device, which left him disgusted and heart-broken. E-Coli was only mentioned briefly in Big Willy Unleashed.
- Destroy All Humans! Big Willy Unleashed (Mentioned only)