Ecoli was Orthopox's girlfriend as he worked at the Palace as a summer job, he had to clean the Emperor's butt. She is likely the Princess of the Furon species, given that her father was the emperor. It was revealed that she was just using him to get back at her father.
As Meningitis' daughter she was very wealthy and she dumped Pox because she was bribed by her father with a new transportation device. Pox often refers to rich women as "Vipers!!!" as a result.