Ecoli was Orthopox's girlfriend as he worked at the Palace as a summer job and had to clean the Emperor's butt. Ecoli was likely the Princess of the Furons, given that her father was the Emperor. It was revealed that Ecoli just used Pox to get back at her father.
As Emperor Meningitis' Daughter, Ecoli was very wealthy and she dumped Pox because she was bribed by her father with a new transportation device. Pox often referred to rich women as "Vipers!!!" as a result.
- Destroy All Humans! Big Willy Unleashed (Mentioned only)