The casino plays an important role in the early stages of Path of the Furon. It's run by the mob brothers, the Moriartis, who have sent a spy to gather information on the Space Dust. Crypto infiltrates the mob's casino and destroys the interior, driving out the customers, causing the mob to go to war with him. He defeats the mob, destroying their profits and taking control of Las Paradiso. After Crypto defeats the Nexosporidium warriors, Pox orders Crypto to destroy all of Paradiso, including the Palazzo. Although it is destroyed after the main missions in Paradiso, it still stands if you return.